Endocrine Abstracts

Type 2 diabetes is a metabolic disorder characterised by insulin resistance and is associated with diminished signalling through the insulin receptor. Protein tyrosine phosphatase 1B (PTP1B), encoded by the PTPN1 gene, has been shown to attenuate insulin’s actions by de-phosphorylating the activated insulin receptor and downstream signalling components such as IRS1. Several studies have highlighted PTP1B as a potential therapeutic target for type 2 diabetes and obesity; h...